Most Read Article June 2008 from Evidence-Based Mental Health – Citalopram-resistant depression: cognitive therapy and medication similarly effective as second line treatments

Citalopram-resistant depression: cognitive therapy and medication similarly effective as second line treatments, Evidence-Based Mental Health 2008;11:48

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Abstract:

Cognitive therapy or pharmacotherapy as second-line for people with citalopram-resistant depression—which is more effective.

304 out-patients with non-psychotic major depressive disorder (clinically established diagnosis verified through DSM-IV criteria) enrolled in the Sequenced Treatment Alternatives to Relieve Depression (STAR*D) study who did not achieve remission (remission defined as Quick Inventory of Depressive Symptomatology score 5) with first-line citalopram treatment. This analysis included only those people who agreed to be randomised to treatment strategies (augmentations, switches or both) which would allow cognitive therapy to be compared with pharmacotherapy.